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Psychologs Magazine
@psychologsmagazine
10.04.2026 15:25
The strongest genetic risk factor for Alzheimer’s, APOE4, may begin affecting the brain long before any visible symptoms appear. Research suggests that this gene triggers subtle yet significant changes inside neurons, leading to their shrinkage and reduced efficiency. These early alterations can quietly disrupt brain activity, making individuals more vulnerable to memory loss and cognitive decline later in life.

https://www.psychologs.com/new-research-reveals-how-apoe4-causes-brain-cell-shrinkage-years-before-alzheimers/

#Alzheimers #BrainHealth #Neuroscience #Psychology #MentalHealth #APOE4 #CognitiveDecline #Neurobiology #BrainResearch #MemoryLoss #HealthyBrain #ScienceFacts #NeuroScience #MindMatters #AgingBrain #MentalWellness #ResearchUpdate
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New Research Reveals How APOE4 Causes Brain Cell Shrinkage Years Before Alzheimer’s
In research conducted at the Gladstone Institute, the neurologists have uncovered something highly unusual. They identified that changes inside the human brain start occurring years before people start suffering from issues with memory or cognitive decline due to old age. The neurologists have identified the specific molecular chain reaction; this is responsible for such changes. Not only this, but the neurobiologists have also identified a way through which these changes can be reversed.  APOE4 Drives brain shrinking, how a risk gene weakens neurones The main purpose behind this research was to study in great detail how the protein of APOE4 puts its effect on the neurons at different stages of a person's life. The team of neurologists working on this research discovered that APOE4 within neurons results in the overproduction of Nell 2, a protein,  which causes the neuron to physically shrink from its original size. Therefore,  all these act as a direct…
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