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Psychologs Magazine
@psychologsmagazine
14.03.2026 12:54
Depression treatment has long relied on medications that take weeks or even months to show results. But what happens when those treatments don’t work? For nearly one-third of people with Major Depressive Disorder, traditional antidepressants fail to provide relief. This condition, known as treatment-resistant depression, leaves many individuals searching for alternatives. In recent years, ketamine therapy has emerged as a groundbreaking development in mental health care. Once known primarily as an anaesthetic, ketamine is now being studied and used for its rapid antidepressant effects, sometimes reducing symptoms within hours. By acting on the brain’s glutamate system, ketamine may help restore neural connections involved in mood regulation, offering new possibilities for people who have struggled with conventional treatments.

https://www.psychologs.com/ketamine-therapy-a-new-hope-for-depression/

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Ketamine Therapy: A New Hope for Depression
Consider a clinical environment in which the quality of care in treating depression has been stagnant at almost 40 cents. The trial-and-error clinical experience of antidepressants, be it selective serotonin reuptake (SSRI) or serotonin-norepinephrine reuptake inhibitors (SNRIs), offers little more than a list of side effects and a continued feeling of hopelessness to millions of people. About a third of patients suffering from major depressive disorder do not respond well to conventional treatments in the United States alone, and the situation is termed treatment-resistant depression (TRD). Ketamine has been added to this therapeutic emptiness not only as a drug of last resort, but as a paradigm change in the medical profession regarding the biology of mental suffering. After being pushed to the operating room as an anaesthetic or the underground as a recreational dissociative, ketamine now takes centre stage in a psychiatric revolution; it has provided quick reprieve to those…
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